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Description:Additional descriptions From OMIM Opitz-Kaveggia syndrome OKS is an X-linked recessive mental retardation syndrome characterized by dysmorphic features, including relative macrocephaly, hypertelorism, downslanted palpebral fissures, prominent forehead with frontal hair upsweep, and broad thumbs and halluces. Most have hypotonia, constipation, and partial agenesis of the corpus callosum. Some patients have sensorineural hearing loss and joint laxity evolving into joint contractures. Affected individuals tend to be hyperactive and talkative summary by Graham et al. In their original family, Opitz and Kaveggia named the disorder 'FG syndrome' according to the Opitz system of using initials of patients' surnames.
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